When a sudden plague of blindness devastates a city, a small group of the afflicted band together to triumphantly overcome the horrific conditions of their imposed quarantine.

Rose, a desperate mother takes her adopted daughter, Sharon, to the town of Silent Hill in an attempt to cure her of her ailment. After a violent car crash, Sharon disappears and Rose begins a desperate search to get her back. She descends into the center of the twisted reality of a town's terrible secret. Pursued by grotesquely deformed creatures and townspeople stuck in permanent purgatory, Rose begins to uncover the truth behind the apocalyptic disaster that burned the town 30 years earlier.