After learning that her sister, Faith, has committed suicide in Portugal, Phoebe, an 18-year-old hippie, decides to uproot from her San Francisco home to travel to Europe. Phoebe hopes to discover and experience the life that led to her sister's death by retracing her footsteps, which eventually leads to Wolf -- Faith's boyfriend. However, as Phoebe's journey continues, a series of visions of Faith pushes her mind to the brink.

Sydney Fox is a professor and globe-trotting "relic hunter" who looks for ancient artifacts to return to museums and/or the descendants of the original owner. She is aided by her linguistic assistant Nigel and occasionally by her somewhat air-headed secretary Claudia. She often ends up battling rival hunters seeking out artifacts for the money.