The Lionians, a tribe of lion worshippers, make a desperate attempt to find a cure for the mysterious disease plaguing their village. Their Chief decides to kidnap Jane and Lola, a half-breed nurse, in order to help repopulate his civilization. Tarzan must rescue them while fending off blowgun attacks from people called the Waddies who are disguised as bushes.

Notorious shootist and womanizer Quirt Evans' horse collapses as he passes a Quaker family's home. Quirt has been wounded, and the kindly family takes him in to nurse him back to health against the advice of others. The handsome Evans quickly attracts the affections of their beautiful daughter, Penelope. He develops an affection for the family and their faith, but his troubled past follows him.

A fatally shot female gangleader recounts her sordid life of crime to a police officer just before she dies.