Liz Lemon, the head writer for a late-night TV variety show in New York, tries to juggle all the egos around her while chasing her own dream.

Based on the true life experiences of poet Jimmy Santiago Baca, the film focuses on half-brothers Paco and Cruz, and their bi-racial cousin Miklo. It opens in 1972, as the three are members of an East L.A. gang known as the "Vatos Locos", and the story focuses on how a violent crime and the influence of narcotics alter their lives. Miklo is incarcerated and sent to San Quentin, where he makes a "home" for himself. Cruz becomes an exceptional artist, but a heroin addiction overcomes him with tragic results. Paco becomes a cop and an enemy to his "carnal", Miklo.

Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.

Mac, the two-fisted, savvy cop finds that he's being saddled with a new partner, a known burnout, to work with him on a new and difficult case. The new partner is Ellis, an amazing detective, one who puts Sherlock Holmes to shame with his lightning-fast deductions. But he keeps assuming the personalities of entire casts of Television shows. This can be a problem when people begin shooting at them.

While Popeye Doyle is investigating what appears to be a very simple drug overdose, he becomes involved in international intrigue. The Mosad and various other foreign diplomatic figures turn up everywhere he goes. The drug overdose becomes a very involved murder case.

When the Muppets graduate from Danhurst College, they take their song-filled senior revue to New York City, only to learn that it isn't easy to find a producer who's willing to back a show starring a frog and a pig. Of course, Kermit the Frog and Miss Piggy won't take no for an answer, launching a search for someone to take them to Broadway.