In an underground fight club, blackbelt Travis Brickley is killed after losing to the evil martial arts master Brakus. Travis' death is witnessed by Walter Grady, the son of his best friend Alex Grady. Alex and his partner, Tommy Lee, vow to avenge their friend's death by defeating Brakus and shutting down the fight club.

After years of separation, Irena Gallier and her minister brother, Paul, reunite in New Orleans. When zoologists capture a wild panther, Irena is drawn to the cat – and zoo curator Oliver to her. Soon, Paul will have to reveal the family secret: that when sexually aroused, they revert into predatory jungle cats.