Colin McCormack thinks he has it all - a great job, a steady stream of hot younger guys, and a best friend whose devotion he takes for granted. But when a charming and mercurial intern sweeps him off his feet, Colin sees a chance for something more: A family of his own. What he discovers instead is a shattering secret that may cost Colin everything -- and everyone -- he holds dear.

Lydia is an overweight sales clerk in a trendy home furnishings store, nearing 30. Though she is a member of a Fat Acceptance Group (a movement dedicated to fighting prejudice against overweight people), she is still struggling with complex feelings about her body and its place in the world. Darcy, a recovering-anorexic real estate agent in her mid-20s, is struggling with the same issues from a very different perspective.

Follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital.