Robert McCall finds himself at home in Southern Italy but he discovers his friends are under the control of local crime bosses. As events turn deadly, McCall knows what he has to do: become his friends' protector by taking on the mafia.

Through globalization, many countries have been opened and barriers removed to ensure easy trade, travel and cultural diversity. However, this openness has given opportunities to criminals looking to exploit the system and ultimately threaten our global safety. As Europe has become a "safe house" for criminals eluding law enforcers, a special kind of law enforcement team is needed to handle specific ongoing crimes on a global level. "Crossing Lines" is the story of one such team, made up of five international cops, headed by Captain Daniel. The team - comprised of individuals who have little in common - must learn to live and work under the most dangerous and potentially deadly conditions. Housed in an unused storage section underneath the ICC, this mismatched team faces bureaucratic, jurisdictional and cultural obstacles while traversing continents in pursuit of justice.