With her father on trial, 15-year-old Mignon leaves Paris to stay with her Italian relatives. The rather prim, snooty teen at first struggles to fit in with the more earthy Forbicioni family, each with their own problems. Eventually she bonds with her lovestruck little cousin Giorgio—who'll learn important life lessons over the course of his summer with Mignon.

This time the "amici" (friends) are just four: Necchi, Meandri, Mascetti and Sassaroli. Nevertheless they are older they still love to spend their time mainly organizing irresistible jokes to everyone in every kind of situation. Mascetti is hospitalized in a geriatric clinic. Of course the place become immediately the main stage for all their jokes. After some jokes they decided to place an ultimate incredible and farcical joke to the clinic guests.

Giulia has a one-night stand with a stranger to forget a heartbreak. Aimlessly walking through October city streets to let off steam, she meets a woman who came from Turin seeking an explanation from her partner, who doesn't even want to see her. The two join forces and settle accounts with him. Neither of them feels like going home and being alone, so they spend the whole night wandering around Milan.

A young busker goes around in Milan with his saxophone, whereby he always plays the same tune and he experiences surrealistic adventures throughout the big city. Meanwhile, a wealthy woman from the local "jet set" falls in love with him.

Giulio is a young boy who still does not know which path to take in life, his father puts him in his place in the bank, but he's too lazy to accept. In fact, he lives with his friend Max and they just pick up and exchange women. One day during a photo shoot in London, Max meets a girl, Dora who is going to change their lives.