An American reporter covering a civil war in Nicaragua discovers that four soldiers that he used to know during World War II are there and they are actual vampires fighting their own personal war against an evil Nicaraguan general and his own personal army of vampires terrorizing the country.

A speeding ambulance abducts three beautiful young women to a sinister medical center where someone is making a killing selling healthy human organs on the black market.

Michael Long, an undercover police officer, is shot while investigating a case and left for dead by his assailants. He is rescued by Wilton Knight, a wealthy, dying millionaire and inventor who arranges life-saving surgery, including a new face and a new identity--that of Michael Knight. Michael is then given a special computerized and indestructible car called the Knight Industries Two Thousand (nicknamed KITT), and a mission: apprehend criminals who are beyond the reach of the law. The series depicts Michael's exploits as he and KITT battle the forces of evil on behalf of the Foundation for Law and Government.