Mai and Cañas, a couple of small-time criminals, see their luck change dramatically when a winning lottery ticket lands in their laps.

Felipe wishes to rediscover himself through Santiago. Santiago does not realize that he never ends up knowing someone and will discover what that someone is capable of doing.

Bewildered, Carlos awakens from a nightmare stalked by Death. The dream has a foreboding message, which is not entirely clear to him. Carlos decides to challenge his destiny and face the consequences, but his evil doing ends up shaping his own fate and that of those around him. Macabre by choice, Carlos attempts to tip the scales by changing the course of the plot designed by the gods. In this story,the unsettling city of Mexico is the backdropthat reveals psychological and human postures characteristic of a big city. It is a story where individuals who change their destiny with masks and opportunism manipulate morality, religion and reason for selfish personal gain.

Nacho Libre is loosely based on the story of Fray Tormenta ("Friar Storm"), aka Rev. Sergio Gutierrez Benitez, a real-life Mexican Catholic priest who had a 23-year career as a masked luchador. He competed in order to support the orphanage he directed.

Family and friends try to sabotage the budding romance between a young upper class girl and a humble student.