Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Eight people embark on an expedition into the Congo, a mysterious expanse of unexplored Africa where human greed and the laws of nature have gone berserk. When the thrill-seekers -- some with ulterior motives -- stumble across a race of killer apes.