A biology professor discovers a deadly species of vampire bats are responsible for a series of bizarre murders and now she must find a way to stop them before they are completely out of control.

Cousins, Bo and Luke Duke, with the help of their eye-catching cousin, Daisy and moonshine-running Uncle Jesse, try and save the family farm from being destroyed by Hazzard County's corrupt commissioner, Boss Hogg. Their efforts constantly find the 'Duke Boys' eluding authorities in 'The General Lee', their 1969 orange Dodge Charger that keeps them one step ahead of the dimwitted antics of the small southern town's Sheriff, Roscoe P. Coltrane.

They used to run the country. Now they're running for their lives! Two on-the-lam former Presidents of the United States. Framed in a scandal by the current President and pursued by armed agents, the two squabbling political foes plunge into a desperately frantic search for the evidence that will establish their innocence.