Having eluded the authorities after a series of grisly murders, the pair find sanctuary at the palatial home of Granny Ruth, an eccentric philanthropist who rallies the cause of "Unique Individuals". But even amongst "friends" the pair soon find themselves having to confront their murderous past.

Brian comes under the addictive spell of a parasite with the ability to induce euphoric hallucinations in its hosts.

The zany crew of a New York cable TV station accidentally bounce a signal off the moon, bringing them worldwide attention.