After a successful deployment of the RoboCop Law Enforcement unit, OCP sees its goal of urban pacification come closer and closer, but as this develops, a new narcotic known as "Nuke" invades the streets led by God-delirious leader Cane. As this menace grows, it may prove to be too much for Murphy to handle. OCP tries to replicate the success of the first unit, but ends up with failed prototypes with suicidal issues... until Dr. Faxx, a scientist straying away from OCP's path, uses Cane as the new subject for the RoboCop 2 project, a living God.

Ex-mobster Keaton, now living in a retirement home, narrowly misses being the target of a mob hit. Policemen Jake, an old friend of Keaton's, and Gable, a violent cop who takes an immediate disliking to the aging gangster are called in to keep Keaton safe as well as investigate the hit. There is a turn of events though when Jake is killed by the hit-men...Gable and Keaton are forced to get along while they search for whoever killed their friend and partner. Adding to the challenge, they only have 48 hours to solve this case on their own!